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Sr. Research Scientist-Medicinal Chemistry

San Diego, California

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Req ID R-13126 Title Sr. Research Scientist-Medicinal Chemistry City San Diego State / Province California Country United States Region Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the global by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. Lilly credits its exceptional employees for its success, and recognizes that the key to ongoing achievement lies in attracting and retaining the best people.

The Discovery Chemistry Research and Technologies (DCRT) division at Lilly Biotechnology Center in San Diego is growing! Do you have exceptional Synthetic or Medicinal Chemistry skills with extensive working knowledge of modern synthetic chemistry methodologies, experimental work, isolation/purification techniques and structural analysis of synthetic organic molecules in drug development? Our team seeks someone who understands the whole drug discovery process including lead generation, lead optimization, in vivo pharmacology, ADME, biopharmaceutical science, process development and preclinical safety assessment and submission to the clinic.

We are an innovative and dynamic team looking to enhance our capabilities in drug discovery. We are committed to continually improving our abilities to make life better for patients around the globe. Consider joining our diverse team of scientists if you have a team oriented mentality and are ready to make an impact!

We are looking for someone who can:

  • Keep safety as a top priority at all time, striving toward a proactive safety culture.
  • Formulate hypothesis, design, and synthesize novel small molecules to engage disease modifying targets and contribute significantly to the advancement of drug discovery programs.
  • Use world-class structure-based drug design technologies and partner with expert colleagues in computational chemistry and structural biology to characterize protein-ligand interactions and gain key insights supporting de-novo molecular design.
  • Optimize lead compounds to improve potency, selectivity, physicochemical properties and ADMET to meet the desired target product profiles required to invent high-quality medicines.
  • Deliver high laboratory synthetic efficiency to inform fast-paced SAR iterations through proposal and execution of synthetic routes.
  • Ability to effectively partner and use external CRO resources to implement design ideas and enhance ability to test and form hypotheses.
  • Collaborate with colleagues specialized in high-throughput automated synthesis, route optimization and scale-up to maximize the overall efficiency and productivity of these groups.
  • Proactively partner cross-functionally and across geographies with scientists in areas like pharmacology, translational science, ADME and toxicology, and Legal to address specific program needs, increase overall business acuity and provide them with Medicinal Chemistry perspectives.

Basic Qualifications:

PhD in Organic or Medicinal Chemistry or related field with 3+ years demonstrated experience (or MS with 10+ years demonstrated experience) in supporting drug discovery

Preferred Knowledge, Skills, Abilities, Experiences:

  • Experience with drug discovery at the molecular design stage (small molecules, oral peptides, and/or RNA Therapeutics).
  • Robust track record of scientific contributions including peer reviewed publications, presentations, and/or patents.
  • Demonstrated dedication to mentoring scientific staff.
  • Medicinal Chemistry expertise in pharmaceutical, biotechnology, or academic environments, with demonstrated knowledge of the following domains of Drug Discovery will be highly valued:
    • Lead optimization to improve properties of compounds, optimize in vitro and in vivo potency, selectivity, and ADMET properties.
    • Modern understanding of ligand binding efficiency, energetics, and how to optimize.
    • Demonstrable exposure to new modalities (eg. targeted protein degradations, siRNA, ADCs, oral peptides, etc.) or related discovery chemistry technologies.
    • Biophysical techniques such as X-ray protein structure, SPR, ASMS.
    • Automated Synthesis.
  • Command of scientific informatics and data visualization tools (e.g. TIBCO Spotfire, KNIME) to undertake computationally enabled multi-property optimization approaches.
  • Excellent English language oral and written communication skills, ability to engage effectively as teammate in a multidisciplinary and global environment.
  • Excellent collaboration skills, strong attention to detail, strong problem solving skills, a high level of learning agility, ability to work across functions and within a global and matrixed organization.
  • Scientific creativity and ability to conceptualize independently and in teams solving problems through hypothesis-based experimental design, analysis and integration of complex data sets and mechanism of action insight.
  • Track record of creating and/or leading projects and initiatives, coordinating multiple scientific activities and team members.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide valid proof of vaccination to the company.

To submit resume, visit and apply to Req ID R-13126.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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