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Research Scientist-Computational

San Diego, California

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Req ID 55440 Title Research Scientist-Computational City San Diego State / Province California Country United States Region North America

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

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Responsibilities

The Discovery Chemistry Research and Technology (DCRT) within the Lilly Research Labs is a small molecule organization that spans from target to candidate selection for clinical studies. The Computational Chemistry and Cheminformatics (C3) group in the DCRT organization is seeking a computational scientist. Do you have demonstrated experience in utilizing computational techniques in structure-based design, and in particular in utilization of free energy methods and molecular dynamics in hypothesis creation? You will be a key driver of interdisciplinary drug discovery project teams and drive utilization of free energy methods across computational chemistry organization.

This position includes the following responsibilities:
  • Generate computational models (e.g., homology, pharmacophore, etc.) to help direct synthetic strategies.
  • Create framework for broad utilization of free energy methods across computational chemistry organization
  • Utilize Electron Microscopy images to create three dimensional models
  • Execute experiments using advanced computational techniques to study protein motions, protein-ligand interactions, or protein-protein interactions to understand binding and enable structural design of new molecules.
  • Apply computational techniques such as conformational analysis, structure searches, docking, molecular dynamics simulations, homology modeling, pharmacophore modeling, free energy perturbation, and virtual screening to solve medicinal chemistry research problems.
  • Work as part of a multidisciplinary team of medicinal chemists, structural biologists, biologists, statisticians and toxicologists to provide computational expertise to advance drug discovery projects.
  • Perform large scale data extraction, manipulation, and merging of multiple data sets for statistical analysis and scoring to understand structure activity relationships.
  • Script workflows in various computational software to efficiently perform molecular calculations.
  • Develop a deep understanding and practical, working knowledge of computational chemistry software suites such as MOE, Schrodinger, CHARMM, AMBER, Cresset, Knime, ChemAxon, Macromodel, and Gaussian to apply to computational research.
  • Contribute to the development of desktop applications for medicinal chemists by developing scripts or workflows for efficient use of software and subsequent training of workflows.
55440BR

Basic Qualifications

  • Ph.D. in Computer Science, Cheminformatics, Computational Chemistry, Bioinformatics or related experience

Additional Skills/Preferences

  • Two or more years of academic or industrial experience working in a highly collaborative team.
  • Experience in utilization of Molecular Dynamics in protein systems.
  • Basic experience in scripting or programming languages such as Python, Perl, or C/C++.
  • Strong foundation in organic chemistry or physical chemistry is required
  • Excellent understanding of computational chemistry and cheminformatics methods.
  • Strong oral and written communication skills, organizational and leadership skills

Additional Information

  • The position may require working in an area with allergens and potentially hazardous materials (PHM) may be used by other scientists. The position will involve occasional travel to other research sites to understand and support global Discovery business.
  • Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
  • Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process, please email Lilly Recruiting Compliance. Please note, this email address is intended for use only to request a disability accommodation, please email Lilly Recruiting Compliance for further assistance. Inquiries which are not requests for accommodations may not receive a response.

To submit resume, visit https://www.lilly.com/careers and apply to Req ID 55440.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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