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Principal Research Scientist-Tracer Chemistry Discovery

49406
Principal Research Scientist-Tracer Chemistry Discovery
Philadelphia
Pennsylvania
United States
North America
Local
Avid Radiopharmaceuticals, Inc. (Avid RP), a wholly-owned subsidiary of Eli Lilly and Company, is a molecular imaging company developing diagnostics and biomarkers that improve global health by accelerating the development of new medicines and enabling a tailored approach to healthcare. For more information, visit www.avidrp.com.
This position is for an experienced synthetic organic / medicinal chemist responsible for the synthesis, purification, and characterization of intermediates and novel molecular imaging ligands relevant to neurodegeneration, oncology, and other diseases. Medicinal chemistry optimization of potency, selectivity and tracer properties is required. The ability to lead internal projects and to identify and lead external collaborations is essential.

Responsibilities:

  • Initiate and lead new internal projects and external collaborations
  • Drive selected medicinal chemistry activities to support research and chemical development through strong technical leadership and ability to solve key issues
  • Conduct synthesis and purification of intermediates and new ligands to targets
  • Design and optimization of synthetic routes
  • Conduct medicinal chemistry research to elaborate structure activity relationships
  • Provide expert analysis and guidance to support decision making at all stages of the drug discovery process
  • Provide technical reports and maintain proper research documentation
  • Collaborate with internal functions
  • Strong organizational skills and ability to effectively manage multiple priorities
  • Ability to work both independently and in a team focused environment
  • Demonstrate a commitment to developing around Avid's core competencies: cultivates innovation, drives engagement, ensures accountability, plans and aligns, nimble learning, and manages complexity
49406BR
  • PhD degree
  • Minimum of 5 years of experience in synthetic organic or medicinal chemistry
  • 10 or more years of experience preferred in synthetic organic or medicinal chemistry
  • Demonstrated ability to independently conceive, plan and execute complex synthesis
  • Knowledge of modern purification and characterization techniques including a solid understanding of NMR, mass spectrometry and HPLC analysis
  • Ability to lead and influence cross-functional/cross-discipline teams
  • Ability to be flexible in a dynamic environment
  • Excellent written and verbal communication skills
  • Experience in discovery of PET molecular imaging agents
  • Experience in bioconjugation and analysis of large molecules
  • Knowledge of and ability to maintain NMR and LCMS instruments
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status