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Research Scientist-Cellular Pharmacology

Indianapolis, Indiana

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Req ID R-13390 Title Research Scientist-Cellular Pharmacology City Indianapolis State / Province Indiana Country United States

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

Our team is growing! We are seeking a cellular (or in vitro) pharmacologist to join a dynamic and highly collaborative team of scientists passionate about discovering medicines for multiple therapeutic areas. This person would work within our Molecular Pharmacology group which integrates enzymology, biophysics, cell pharmacology, chemical biology, analytical technologies, fields in structural biology to uncover mechanistic insights necessary to drive drug discovery efforts. Are you looking for an opportunity to lead and innovate in a diverse team and for a great company? Join the Lilly family today!

Responsibilities:

  • Proficient in the development of cellular assays to understand cell signaling pathways in cellular systems and primary cells from normal and diseased states, (e.g. peripheral blood mononuclear cell assays, whole blood assays, neurons, or other disease relevant cellular systems).
  • Experience in the application of modern techniques to understand cellular target engagement and phenotypic responses used to drive small molecule, lead generation strategies. This includes complex disease relevant assays supporting the evaluation of pathways across one or more therapeutic areas (diabetes, pain, neurodegeneration, and immunology).
  • Record of success in bioassay development, compound screening, SAR support, pharmacological characterizations, and/or lead optimization.
  • Ability to help drive the identification of small molecule ligands from screening campaigns and build deconvolution strategies that uncover their cellular mechanism of action.
  • Lead project strategies from both the laboratory and among cross-functional partners.
  • Excellent communication and presentation skills. Strong publication record and/or active engagement in the broader scientific community.

Basic Requirements:

  • PhD in biochemistry, biology, cellular pharmacology, molecular biology, enzymology, or related field or MS degree in similar fields with 5+ years of relevant experience

Additional Skills/Preferences:

  • Post-doctoral experience (preferably in an industrial setting).
  • Ability to integrate cell pharmacology with mechanistic biochemistry, biophysics, and structural biology to provide a complete view of a drug’s molecular mechanism of action.
  • Application of mathematical models to characterize the pharmacology of drug-target interactions.
  • Experience partnering cross-functionally with structural biologists, molecular biologists, protein biochemists, medicinal chemists, computational chemists, ADME scientists, and/or toxicology.
  • Willingness to challenge the status quo and build precedent where none exists.
  • Evidence of a passion for learning and applying new techniques to solve challenging mechanistic questions.
  • More experienced candidates should have a proven track record of driving early drug discovery strategies in a biotech or pharmaceutical setting with broad impact across the scientific community. This includes the ability to lead and mentor other scientists and future leaders.
  • Scientists with primary expertise in a related Molecular Pharmacology capability with secondary cell pharmacology expertise could be considered. Knowledge/experience in the field of chemical biology and chemoproteomics would be an advantage.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-13390.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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