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Postdoctoral Scientist (PAT, SMDD) - FDE

Indianapolis, Indiana

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Req ID R-6109 Title Postdoctoral Scientist (PAT, SMDD) - FDE City Indianapolis State / Province Indiana Country United States

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Synthetic Molecule Design and Development (SMDD) is an innovation-focused organization within Eli Lilly and Company. Our dynamic group is made up of chemists, pharmaceutical scientists, analytical chemists, and engineers. We strive to identify, develop and apply groundbreaking technologies to deliver maximum benefit to our patients. Within SMDD, real-time process monitoring is essential to establishing a robust and sustainable supply chain for small molecules as well as other synthetic molecules such as peptides, oligonucleotides and antibody-drug conjugates. We seek to use new technologies for key problems, and we endeavor to constantly improve the way we develop and manufacture therapeutic molecules.

Are you a creative and innovative analytical chemist? Do you have a unique technical skillset and are you driven to improve those around you? Are you interested in learning about pharmaceutical drug product process development? If the answers are yes, this can be the right position for you to make an impact, acquire valuable training and connections, and improve the future of drug manufacturing. You will have the opportunity to collaborate across scientific areas such as formulation development, analytical chemistry, process modeling and chemical engineering. This role will carrying out basic and applied research as an individual contributor in the development of advanced process analytical technology (PAT) and modeling/optimization tools focused on real-time process monitoring applied to continuous manufacturing process on drug product.

Key Responsibilities:

  • Develop and tests new ideas and/or applies innovative analytical solutions that bring value for a robust real-time process monitoring scheme.

  • Thinks with an end-in-mind approach by strategically developing data reconciliation/state estimate tools for real-time process monitoring.

  • Effectively build a diverse multi-functional, internal, and external network to design & prototype analytical instrumentations for real-time monitoring.

  • Effectively integrate multi-functional information within Synthetic Molecule Design and Development and apply technical knowledge to make decision based on data.

  • Focus on defining clear scientific hypothesis, goals with fit-for-purpose experimental plans and timelines in support of advancing the portfolio

  • Contribute to the general scientific community through external publications and presentations

  • Keep abreast of relevant scientific literature/new technologies/capabilities

  • Ensure work and team activities are aligned with all relevant Development Quality, safety requirements and Team Lilly expectations

Minimum Qualification

  • Ph.D. in Chemistry, Pharmaceutical Sciences, Chemical Engineering

Additional Requirements

  • Preferred knowledge and experience in one or both of the following areas of expertise

  • Spectroscopy-based process monitoring tools (such as NIR and Raman, etc.) and corresponding multivariate data analysis to translate process data to information based decisions

  • Process monitoring and control via maximizing real-time sensing for data reconciliation scheme and/or state estimate

  • General knowledge of analytical instrumentation including operational and maintenance aspects.

  • General knowledge of process monitoring and control with system automation/integration.

  • General knowledge of drug product manufacturing process (such as direct compression and wet granulation process)

  • Understanding of drug product formulations, including an understanding of measurements and implications of the impact of physical and chemical properties on measured signals, is preferred, but not required.

  • Knowledge and understanding of regulatory and quality implications of a real-time monitoring scheme in a regulated environment, is preferred, but not required.

  • Problem solving and decision-making.

  • Demonstration of scientific and people leadership skills.

  • Effective oral and written communication skills.

  • Must be able to work productively in an interdisciplinary team environment.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-6109.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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