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Post-Doctoral Scientist – Mass Spectrometry-Based Metabolomics Research (FDE)

Indianapolis, Indiana

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Req ID R-33715 Title Post-Doctoral Scientist – Mass Spectrometry-Based Metabolomics Research (FDE) City Indianapolis State / Province Indiana Country United States Region Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Are you looking to make a significant difference by contributing to development of gene therapies to address unmet medical needs? If so, this might be a right role for you where you will be working in the highly collaborative Bioproduct Research and Development (BRD) organization within Lilly Research Laboratories (LRL) to develop new manufacturing platform for adeno-associated virus (AAV)-based gene therapies.

About Eli Lilly’s Postdoctoral Scientist Program

When it comes to research and development, our goal is to discover and deliver innovative medicines that make life better for people around the world. It’s challenging, expensive and often filled with failure. But even when we fail, we advance medical science and understanding by learning more about diseases, biology and chemistry – ultimately bringing new solutions one step closer to reality.

Over the course of our history, we have shed light on some of the toughest health care problems known to man – diabetes, heart disease, infectious diseases, neuroscience disorders, cancer and more. We could not pursue this without our research and development team.

Postdoctoral scientists help us continue this pursuit. During your experience you will get:

  • Top industry research experience
  • Mentoring by some of Lilly’s top scientists  
  • Laboratory and classroom training and education to further your development
  • Collaboration and networking across dozens of postdoctoral scientists and other researchers

We are seeking an ambitious post-doctoral scientist with strong research and communication skills to contribute to highly visible gene therapy research and development projects. Your work will provide insights contributing to the development of a world-class cell culture platform for manufacturing AAV gene therapies. In this role, you will:

  • Develop untargeted and targeted metabolomics methods using cutting-edge mass spectrometry technology to study intracellular and extracellular metabolomics of host cells producing AAV.  
  • Systematically study the intracellular and extracellular metabolomics to identify  biomarkers for the cell culture performance, and to identify potential bottlenecks in the critical metabolic pathways of AAV production.
  • Work closely with structural characterization, molecular biology, cell culture development, NMR and analytical teams in BRD.
  • Identify areas of key need across clinical development and champion creative solutions to address those needs. Maintain external awareness and learning to benefit the organization.
  • Present findings at conferences and publish in high quality peer-reviewed journals.

Basic Qualifications

  • PhD in Chemistry, Biochemistry or Biology related field.
  • Strong background in metabolomics research using mass spectrometry.

Additional Skills/Preferences

If you are described with these skills, you could be a great fit for the role:

  • Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
  • Excellent communicator (oral and written) with presentation experience, along with a  strong publication record.
  • Ability to carry out research programs independently and to collaborate effectively with others in a multifunctional team environment.
  • Detailed understanding of established and emerging MS techniques and methodology for metabolomics.
  • Extensive hands-on experience with UPLC/HPLC and advanced mass spectrometry instruments (e.g., TOF, Orbitrap and MRMS).
  • Proficient in analysis of complex metabolomics data and metabolic pathways using state of the art software and metabolomics databases.
  • Experienced with mammalian or insect cell culture.
  • Experience with identification and quantitation of small molecules using NMR.
  • Experience with proteomics and transcriptomics.
  • Familiarity with computer programming languages.

Additional Information

  • Position location: Indianapolis, IN.
  • This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( Lilly_Recruiting_Compliance@lists.lilly.com ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and help our company develop talented individuals for future leadership roles. Our current groups include: Africa, Middle East, Central Asia Network, African American Network, Chinese Culture Network, Early Career Professionals, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinos at Lilly, PRIDE (LGBTQ + Allies), Veterans Leadership Network, Women’s Network, Working and Living with Disabilities. Learn more about all of our groups.


As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company (subject to applicable law). 

#WeAreLilly

To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-33715.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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