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Post-Doctoral Scientist - Automated Crystallization (FDE)

Indianapolis, Indiana

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Req ID R-15856 Title Post-Doctoral Scientist - Automated Crystallization (FDE) City Indianapolis State / Province Indiana Country United States Region Research

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 35,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Responsibilities:

  • Design, integrate and deploy a novel automated experimental setup for crystallization and slurry milling to extract fundamental information for process design in an autonomous way.
  • Develop a 2D morphological population balance model to predict crystal growth, dissolution and morphology evolution during crystallization, dissolution and milling operations and compare the results with other state of the art modeling approaches.
  • Develop a control strategy for particle size and morphology manipulation. Deploy combined experimental and modeling approaches to achieve an automated process implementation.
  • Apply insight gained from basic research to develop a workflow to efficiently design crystallization processes.
  • Sit at the exciting interface between drug substance (the active pharmaceutical ingredient or API) and drug product to see how physical properties of powders can impact the development of drugs. 
  • Build first in class workflows to automate process development in particle engineering field.
  • Focus on defining robust strategies to account for API’s unique chemistry and crystallization kinetics for API isolation and impurity rejection.
  • Learn to manipulate the physical properties of powders through particle design.
  • Apply a data driven strategy for decision making
  • Build a diverse, multi-functional network through collaboration both within Lilly and with external partners.
  • Publish and present relevant research findings both within Lilly and externally.
  • Stay on top of relevant scientific literature/new technologies/capabilities.

Minimum Qualifications:

  • Ph.D. in chemical engineering, physical chemistry, mechanical engineering, materials engineering or a related field.

Additional Skills/Preferences:

  • Strong analytical skills for integrating and interpreting complex data sets
  • Effective written and oral communication skills
  • Small molecule crystallization research experience
  • Automation experience (hardware and software) preferably with deltaV
  • Must be able to work efficiently in an interdisciplinary team environment
  • Detailed understanding of crystallization modeling techniques.
  • Experience with data interpretation, i.e. the application of chemometrics, multivariate modeling, or other data analysis tools.
  • A firm understanding of thermodynamics and kinetics of crystallization processes.
  • Knowledge of solid-state characterization tools and techniques
  • Good interpersonal skills and a sustained tendency for collaboration.
  • Self-directed and highly motivated individual who wants to learn new techniques while continually pursuing research and publication goals.
  • Excellent communicator (oral and written) with presentation experience, along with a strong publication record.
  • Strong dedication to research in a team environment

This position is not permanent. It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years.


Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

As a condition of employment with Eli Lilly and Company and its subsidiaries in the United States and Puerto Rico, you must be fully COVID-19 vaccinated and provide proof of vaccination satisfactory to the company.  If you would like to request an accommodation for medical or religious reasons, you may do so at workplace_adjustment@lilly.com. 

To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-15856.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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