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Research Scientist-Cell Biology-Neurodegeneration

Cambridge, Massachusetts

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Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help with individuals with disabilities participate in the workforce and ensure equal opportunity to compete for jobs. If you are an individual with a disability and require a reasonable accommodation to participate in the application process for positions at Lilly please email Lilly Recruiting Compliance for further assistance. Please note, this email address is intended for use only to request an accommodation as a part of the application process. Any other correspondence will not receive a response.

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Req ID 54598 Title Research Scientist-Cell Biology-Neurodegeneration City Cambridge State / Province Massachusetts Country United States Region North America

Company Overview

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world. #WeAreLilly


Eli Lilly has a proud record of drug discovery and development for Alzheimer’s Disease with a highly competitive portfolio of industry leading assets. We are now seeking a highly motivated scientist to join the Neurodegeneration team to facilitate its mission of discovering novel medicines for the treatment of Alzheimer’s disease, Parkinson’s disease, and other related neurodegenerative conditions.

As part of our Proteostasis Group, which is part of the larger Neurodegeneration division, you will contribute to driving experimental programs to develop new therapeutics for neurodegenerative diseases. Do you have the confidence to drive your own research while contributing to the broader team?

We are looking for a passionate teammate who has a strong knowledge of the cellular biology of neurodegenerative disease and/or protein degradation pathways. Expertise in human iPSC culture, in particular differentiation of iPSCs into neurons is beneficial, as is knowledge of cellular imaging and biochemical techniques, ideally related to tau/misfolded proteins or protein degradation mechanisms.

Responsibilities may include:

  • Design and implement a program of work to support efficient progression of in vitro projects addressing key molecular mechanisms and testing new chemical entities. Working independently to troubleshoot and drive forward an experimental program.
  • Developing new areas of research, novel approaches, targets and techniques to help Lilly expand its capabilities in neurodegenerative disease.
  • Maintenance and manipulation of human iPSC cells, differentiation into neurons and performing biochemical, imaging or functional assays in these cells.
  • Working with other cell systems, for example primary neuronal culture or immortalised cell lines and manipulations of these cells (e.g. viral transfection, siRNA knock-down, genetic manipulation, co-culture) to increase target validation for various molecular pathways.
  • Measurement of biochemical or functional parameters in cells using techniques including microscopy, live fluorescence imaging, immunocytochemistry, calcium imaging, morphology, live/dead cell assays.
  • Performing assays that might include: AlphaScreen, ELISA, MSD, SDS-PAGE, WB , FACS.
  • Provide written and verbal communication of work to internal and external collaborators.
  • Accurate recording of all practical work: completion of electronic lab notebook to Lilly procedure quality standards;
  • Maintaining high laboratory standards with regard to quality and safety.

Basic Qualifications

  • PhD in a neuroscience-related or similar discipline

Additional Skills/Preferences

  • Strong background in neuronal cell culture as well as assay development.
  • Ability to work independently as well as in a team-orientated environment.
  • Ability to multi-task and efficiently handle varied experiments while maintaining quality results and attention to detail.
  • Ability to review literature and rapidly prepare and analyse data for presentation at team, group, departmental meetings.
  • Good knowledge of genetics and common molecular mechanisms contributing to neurodegeneration.
  • Experience with leading drug/scientific discovery teams would be an advantage
  • Ability to prepare and present data at external meetings, experience and track record of presenting and/or publication of data.

Additional Information

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

To submit resume, visit and apply to Req ID 54598.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

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