Research Scientist - Chemo - Informatician
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The Discovery Chemistry Research and Technologies (DCRT) organization within Lilly Research Labs is a small molecule drug discovery organization with responsibilities spanning from target identification to candidate selection for clinical studies. We are looking to grow our diverse team of scientists. The Computational Chemistry and Cheminformatics (C3) group in DCRT is seeking an experienced cheminformatics scientist to contribute to the application, evolution, and transformation of the Eli Lilly DNA-encoded library (DEL) platform.
Some key responsibilities:
Contribute strategically to the application, evolution, and transformation of the DEL platform.
Contribute to overall hit finding strategy, leveraging both wet-lab and computational screening technologies.
Work closely with project teams across the portfolio to drive broad application of DEL and delivery of actionable hits in a timely manner.
Development and / or incorporation of scientific software to perform large scale cheminformatics tasks such as library design, predictive modeling, building block selection, reaction informatics and data analysis related to the DEL platform.
Evolve the DEL collection based on Lilly’s target portfolio.
Develop meaningful metrics to evaluate the performance of the DEL platform.
Evolve visualization and noise reducing methods for effective hit identification, validation, and expansion.
Contribute to the selection, establishment, and management of partnerships with external DEL-related technology or service providers, especially in cheminformatics, data management and data analysis aspects.
Act as the liaison between the DEL team and the broader DCRT team and therapeutic areas.
Ph.D. in Computer Science, Cheminformatics, Computational Chemistry, Bioinformatics or related field and 8+ years’ experience within biotech or pharma industrial environment.
Demonstrated contributions to DEL platform development, including library design, informatics workflow and data analytics.
Demonstrated contributions in hit finding for therapeutic projects through the application of DEL.
Experience leveraging artificial intelligence/machine learning (AI/ML) and/or data analytics for applications in DEL and/or virtual library design.
Project-level focus and ability to influence cross functionally.
Experience in Python scripting.
Strong oral and written communication skills, organizational and leadership capabilities.
Experience mentoring and teaching other computational scientists.
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To submit resume, visit https://www.lilly.com/careers and apply to Req ID R-28848.
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.
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